Incazelo emfushane:
Inombolo ye-CAS:472-15-1
Ifomula yemolekyuli:C30H48O3
isisindo se-molecule: 456.71
Isakhiwo samakhemikhali:
| Ulwazi Oluyisisekelo | |
| Igama lomkhiqizo | I-Betulinic acid |
| Ibanga | Ibanga le-Pharma |
| Ukubukeka | Okumhlophe noma okumhlophe |
| Isivivinyo | 98% |
| Impilo yeshelufu | iminyaka engu-2 |
| Ukupakisha | 25kg/isigubhu |
| Isimo | Izinzile, kodwa igcina ipholile. Akuhambisani nama-oxidizing agents aqinile, i-calcium gluconate, i-barbiturates, i-magnesium sulfate, i-phenytoin, amavithamini e-sodium eqembu B. |
Incazelo
I-Betulinic acid (472-15-1) i-Lupane triterpenoid yemvelo evela esihlahleni se-birch esimhlophe (Betula pubescens). Idala i-apoptosis emigqeni yamaseli ehlukahlukene.1 Idala ukuvuleka kwembotshana ye-mitochondrial permeability.2 ?Isebenza njenge-chemosensitizer yokwelashwa kwezidakamizwa ezilwa nomdlavuza emigqeni yamaseli omdlavuza wekholoni we-chemoresistant.3 Iseli liyangeneka.
Sebenzisa
I-Betulinic Acid iyi-pentacyclic triterpenoid yemvelo. I-Betulinic Acid ibonisa umsebenzi wokulwa nokuvuvukala kanye ne-anti-HIV. I-Betulinic Acid ikhetha ngokukhetha i-apoptosis kumaseli wesimila ngokuvula ngokuqondile indlela ye-mitochondrial ye-apoptosis ngokusebenzisa indlela ezimele ye-p53- ne-CD95. I-Betulinic Acid futhi ikhombisa umsebenzi we-agonist we-TGR5.
I-Betulinic acid (BetA) isetshenzisiwe:
1.ukuhlola imiphumela yayo njenge-antiviral virus ngokumelene ne-Dengue virus (DENV).
2.njenge-sterol regulatory element-binding protein (SREBP) inhibitor ukucindezela i-lipid metabolism kanye nokwanda kwamaseli acacile we-cell renal cell carcinoma (ccRCC).
3.njengokwelapha ukuhlola izakhiwo zayo zokulwa nesimila ukuze kusebenze iseli kanye nokuhlolwa kokufa kwamaseli e-apoptotic kumamodeli amaningi e-myeloma.
Ucwaningo lwe-Anticancer
Le nhlanganisela i-pentacyclic triterpene etholakala ezinhlotsheni ze-Betula ne-Zizyphus, ebonisa i-cytotoxicity ekhethiwe ngokumelene namaseli e-melanoma yabantu (Shoeb2006). Ikhiqiza izinhlobo ze-oksijini esebenzayo, yenza kusebenze i-MAPK cascade, inhibitstopoisomerase I, inhibits angiogenesis, modulates pro-growth transcriptionalactivators, modulates umsebenzi we-aminopeptidase-N, futhi ngaleyo ndlela inducesapoptosis kumaseli omdlavuza (Desai et al. 2008; Fulda 2008).
Umsebenzi Webhayoloji
I-triterpenoid yemvelo ebonisa i-anti-HIV nomsebenzi we-antitumor. Idala ukukhiqizwa kwezinhlobo ze-oxygen esebenzayo (ROS) futhi isebenze i-NF- κ B. Ibonisa umsebenzi we-agonist we-TRG5 (EC 50 = 1.04 μ M).
Izenzo ze-Biochem/physiol
I-Betulinic acid, i-pentacyclic triterpene, ikhetha ngokukhetha i-apoptosis kumaseli wesimila ngokuvula ngokuqondile indlela ye-mitochondrial ye-apoptosis ngokusebenzisa indlela ezimele ye-p53- ne-CD95.
