Incazelo emfushane:
Inombolo ye-CAS: 126-07-8
Ifomula yemolekyuli:C17H17I-ClO6
isisindo se-molecule: 352.77
Isakhiwo samakhemikhali:
| Ulwazi Oluyisisekelo | |
| Igama lomkhiqizo | I-Griseofulvin |
| Ibanga | Ibanga lezemithi |
| Ukubukeka | Impushana emhlophe ukuya kophuzi-mhlophe |
| Isivivinyo | 99% |
| Impilo yeshelufu | iminyaka engu-2 |
| Ukupakisha | 25kg/ibhokisi |
| Isici | Ayincibiliki kalula emanzini, incibilika ngokukhululeka ku-dimethylformamide kanye ne-tetrachloroethane, incibilika kancane ku-ethanol anhydrous kanye ne-methanol |
| Isimo | Gcina isitsha sivaliwe endaweni eyomile, engenawo umoya. |
Incazelo ejwayelekile yeGriseofulvin
I-Griseofulvin iyi-non-polyene class antibiotics antifungal;ingavimbela ngokuqinile i-mitosis ye-fungal cell futhi iphazamise ukuhlanganiswa kwe-fungal DNA;ingaphinde ibophe ku-tubulin ukuvimbela ukuhlukana kwamaseli we-fungal.Isetshenziswe emithini yomtholampilo kusukela ngo-1958 futhi njengamanje isetshenziswa kabanzi ukwelapha izifo zesikhunta esikhumbeni kanye ne-stratum corneum enemiphumela enamandla yokuvimbela i-Trichophyton rubrum kanye ne-Trichophyton tonsorans, njll. I-Griseofulvin ayisona nje isibulala-magciwane esisetshenziswa kakhulu emitholampilo. ukwelashwa kwezifo zesikhunta esikhumbeni kanye ne-cuticle, kodwa futhi kusetshenziswe kwezolimo ukuvimbela nokwelashwa kwezifo zokukhunta;isibonelo, inokusebenza okukhethekile ekwelapheni uhlobo lwe-candidiasis e-apula olungabangela ukutheleleka ngesikhathi sokuvuthwa.
Izimpawu zeGriseofulvin
Kwezokwelapha,lo mkhiqizo ulungele ukwelapha izinhlobonhlobo zezikelemu, okuhlanganisa i-tinea capitis, i-tinea barbae, i-body tinea, i-jock itch, i-foot tinea kanye ne-onychomycosis.Izinhlobo ezihlukahlukene ze-tinea okukhulunywe ngazo zibangelwa isikhunta esihlukahlukene okuhlanganisa i-Trichophyton rubrum, i-Trichophyton tonsorans, i-Trichophyton mentagrophytes, i-Fingers Trichophyton, njll., kanye ne-Microsporon audouini, i-Microsporon canis, i-Microsporon gypseum ne-Epidermophyton floccosum, njll.Lo mkhiqizo awufanele ukwelashwa ezimeni ezithambile, izimo zokutheleleka kwendawo kanye nezimo ezingelashwa ngama-topical antifungal agents.I-Griseofulvin ayisebenzi ekwelapheni izifo zezinhlobo ezihlukahlukene zesikhunta njenge-Candida, i-Histoplasma, i-Actinomyces, izinhlobo ze-Sporothrix, i-Blastomyces, i-Coccidioides, i-Nocardio ne-Cryptococcus kanye nokwelapha i-tinea versicolor.
Kwezolimo,lo mkhiqizo wethulwa okokuqala nguBrian etal (1951) ukulawula izifo zezitshalo.Ngokusho kocwaningo lwangaphambilini, ingasetshenziswa ukuvimbela ukubola kwekhabe (ikhabe) umvini, isifo sokusakazeka kwe-crack, i-watermelon blight, i-anthracnose, i-apula blossom rot, i-apula cold rot, i-apula rot, i-cucumber downy mildew , isikhunta esimpunga se-strawberry, i-gourds elengayo. , i-powdery mildew of roses, i-chrysanthemums powdery mildew, i-rot flower lettuce, i-tomato blight yakuqala, i-tulip fire blight nezinye izifo zesikhunta.
