Incazelo emfushane:
Inombolo ye-CAS: 55268-74-1
Ifomula yemolekyuli:C19H24N2O2
isisindo se-molecule: 312.41
Isakhiwo samakhemikhali:
| Ulwazi Oluyisisekelo | |
| Igama lomkhiqizo | I-Praziquantel |
| Ibanga | Ibanga le-Pharma |
| Ukubukeka | Imhlophe noma icishe ibe mhlophe i-crystalline powder |
| Isivivinyo | 99% |
| Impilo yeshelufu | iminyaka engu-2 |
| Ukupakisha | 25kg/isigubhu |
| Isici | Incibilika ngokukhululekile ku-ethanol noma ku-dichloromethane.Incibilika kancane emanzini |
| Isimo | Ivalwe endaweni eyomile, Gcina efrijini, ngaphansi kuka -20°C |
Incazelo
I-Praziquantel (PZQ) iphuma ku-isoquinoline enomsebenzi omningi webhayoloji otholakala ku-levo enantiomer.I-compound ayinawo umsebenzi wokulwa nama-nematodes, kodwa iphumelela kakhulu ngokumelene nama-cestodes nama-trematodes.
I-Pharmacology kanye nendlela yokusebenza
I-Praziquantel iyinhlanganisela ye-pyrazinoquinoline eyakhelwa ukwelapha i-schistosomiasis kodwa kutholakale ukuthi inohlobo olubanzi lomsebenzi we-anthelminthic.I-Praziquantel iyi-racemate kodwa i-enantiomer engu-R (+) yiyona kuphela ebophezelekile ngomsebenzi wayo wokulwa nezinambuzane.Isebenza ngokumelene nama-trematodes (zonke izinhlobo ze-Schistosoma pathogenic kumuntu, i-Paragonimus westermani, ne-Clonorchis sinensis) kanye nama-cestodes (i-Taenia saginata, i-Taenia solium, i-Hymenolepis nana ne-Diphyllobothrium latum) .
Indlela yokusebenza ye-praziquantel ayaziwa ngokucacile.I-Schistosomes ithatha umuthi ngokushesha.Ukuthathwa kwezidakamizwa ngokushesha kulandelwa ukwanda kwemisipha okuholela ekufinyezweni kwe-tetanic kanye nokukhishwa kwe-parasite tegument .
Imiphumela yemisipha yomuthi kucatshangwa ukuthi inesibopho sokugudluzwa kwezimuncagazi zisuka emithanjeni ye-mesenteric ziye esibindini ku-vivo.Kodwa-ke, ukuguquguquka kwesibindi kuye kwaboniswa ngama-schistosomicides aziwa kakhulu futhi angase anganikezi noma yiluphi ulwazi oluthile lwendlela yokusebenza yomuthi.Okutholwe kokuhlolwa kwakamuva kuphakamise ukuthi imiphumela ye-antischistosomal yomuthi ihlobene nomthelela wayo ku-tegument kunasemisipha.
Omunye umphumela we-pharmacological womuthi uhlanganisa ukwanda kwe-membrane permeability kuma-cations, ikakhulukazi i-calcium.
Kodwa-ke, indima yalo mphumela endaweni ye-anthelminthic yomuthi ayaziwa.
Isicelo
Iwuhlobo lomuthi we-broad-spectrum anti-parasitic disease.Ingasetshenziswa ekwelapheni nasekuvimbeleni i-schistosomiasis, i-cysticercosis, i-paragonimiasis, isifo se-hydatid, i-fasciolopsiasis, isifo se-hydatid, kanye nokutheleleka kwezikelemu.
Ingasetshenziswa futhi njenge-anthelmintic futhi iyasebenza ekwelapheni i-nematodes yezilwane zamathumbu.Ingaxutshwa ku-feed ukuze ifakwe.
Umkhiqizo uwuhlobo lomuthi we-anthelmintic osebenza kahle ekwelapheni i-Schistosoma japonicum, i-Schistosoma mansoni ne-Schistosoma haematobium, i-Clonorchis sinensis, i-Paragonimus westermani, i-fasciolopsis buski, izikelemu ze-tapeworm kanye ne-cysticercosis.Inamandla kakhulu okubulala izikelemu ze-tapeworm futhi okwamanje isebenza kahle kakhulu phakathi kwesidakamizwa esilwa neschistosomiasis.
Iwuhlobo lomuthi we-anthelmintics osetshenziswa kakhulu ukwelapha i-schistosomiasis.Ingasetshenziselwa futhi ukwelapha i-Fahrenheit schistosomiasis, i-taeniasis, i-paragonimiasis, kanye ne-cysticercosis.
