Incazelo emfushane:
Inombolo ye-CAS: 38821-53-3
Ifomula yemolekyuli: C16H19N3O4S
isisindo se-molecule: 349.4
Isakhiwo samakhemikhali:
| Ulwazi Oluyisisekelo | |
| Igama lomkhiqizo | I-Cefradine |
| Ukuzinza | Ukukhanya Okuzwelayo |
| Ukubukeka | Impushana emhlophe |
| Isivivinyo | 99% |
| Iphoyinti lokuncibilika | 140-142 C |
| Ukupakisha | 5KG;1KG |
| Iphuzu elibilayo | 898℃ |
Incazelo
I-Cefradine (eyaziwa nangokuthi i-cephradine), 7-[D-2-amino-2(1,4cyclohexadien1-yl) acetamido]-3-methyl-8-0x0-5thia-l-azabicyclo[4.2.0] oct-2- I-ene-2-carboxylic acid monohydrate (i-111 iyi-semi-synthetic cephalosporin antibiotic. isetshenziswa ngomlomo, nge-intramuscularly, nangomjovo. Ukwakheka kwe-cephradine kuyafana ne-cephalexin, umehluko kuphela oseringini enamalungu ayisithupha. I-Cephalexin inamathathu amathathu. amabhondi aphindwe kabili enza uhlelo olunephunga elimnandi kuyilapho i-cephradine inezibopho ezimbili eringini efanayo[1].
Umfanekiso1 ukwakheka kwamakhemikhali e-cefradine;
I-Cephradine i-white crystalline powder enesisindo samangqamuzana angu-349.4[2]. Ukuhlanganiswa kwe-cephradine kuxoxwe ngakho[3]. I-Cephradine incibilika ngokukhululekile kuzincibilikisi ezinamanzi. I-zwitterion, equkethe kokubili iqembu le-alkaline amino kanye neqembu le-acidic carboxyl. Ebangeni le-pH lika-3-7, i-cephradine ikhona njengosawoti wangaphakathi[4]. I-Cephradine izinzile amahora angama-24 ku-25" ngaphakathi kwebanga le-pH lika-2-8. Njengoba izinzile emithonjeni ye-acidic, kukhona ukulahleka okuncane komsebenzi oketshezini lwesisu; ukulahlekelwa okungaphansi kuka-7% kubikiwe.[5].
I-Cephradine iboshelwe ngokubuthakathaka kumaprotheni e-serum yomuntu. Umuthi wawungaphansi kuka-20% uboshelwe kumaprotheni e-serum[4]. Ekugxilweni kwe-serum ye-10-12 pg/ml, u-6% wesamba somuthi wawusendaweni eboshwe ngamaprotheni. Esinye isifundo[6]ithole ukuthi ekuhlanganiseni okuphelele kwe-10 pg / ml, i-28% yomuthi yayisesimweni esiboshwe ngamaprotheni; ekuhlanganiseni okuphelele kwe-100 pg / ml, i-30% yomuthi yayisesimweni esiboshwe ngamaprotheni. Lolu cwaningo luphinde lwabonisa ukuthi ukungezwa kwe-serum ku-cephradine kunciphisa umsebenzi wama-antibiotic. Esinye isifundo[2]ibonise ukuthi ukubopha amaprotheni e-cephradine kuyahlukahluka kusuka ku-8 kuya ku-20%, kuye ngokugxila komuthi. Nokho, ucwaningo olwenziwa nguGadebusch et al.[5]angatholanga shintsho ku-MIC ye-cephradine ngaku-Staphylococcus aureus noma i-Escherichia coli ngemva kokwengezwa kwe-serum yomuntu.
Izinkomba
I-Cephradine iyasebenza ku-vitro ngokumelene nenani elibanzi lamabhaktheriya e-gram-positive kanye ne-gram-negative, kuhlanganise nezilwanyana ze-pathogenic ezihlukaniswe emtholampilo; i-compound iboniswe ukuthi ine-asidi ezinzile, futhi ukungezwa kwe-serum yomuntu kube nomthelela omncane kuphela ekugxilweni okuncane kwe-inhibitory (MIC) yezinto eziphilayo ezibucayi. Lapho inikezwa ngomlomo noma ngaphansi kwesikhumba ezilwaneni ezitheleleke ngokuvivinywa ngamabhaktheriya e-pathogenic ahlukahlukene, i-cephradine inikeza isivikelo esisebenzayo.[16]. Ekwelapheni izifo ezithathelwanayo eziyingozi, izimpendulo zemitholampilo ezanelisayo ekwelashweni kwe-cephradine ziye zabikwa ngabaphenyi abaningi.[14, 15, 17-19].
