Incazelo emfushane:
Inombolo ye-CAS: 1197-18-8
Ifomula yemolekyuli: C8H15NO2
isisindo se-molecule: 157.21
Isakhiwo samakhemikhali:
| Ulwazi Oluyisisekelo | |
| Igama lomkhiqizo | I-Tranexamic Acid |
| Ibanga | Ibanga Lokuzimonyo |
| Ukubukeka | Impushana emhlophe noma ecishe ibe mhlophe |
| Isivivinyo | 99% |
| Impilo yeshelufu | iminyaka engu-2 |
| Ukupakisha | 25kg/isigubhu |
| Chemical Properties | Incibilika ngokukhululeka emanzini naku-glacial acetic acid futhi incibilika kancane ku-ethanol futhi ayincibiliki ku-ether. |
Incazelo
I-Tranexamic acid iphuma ku-aminomethylbenzoic acid, kanye nohlobo lwemithi ye-antifibrinolytic yokumisa ukopha. Indlela ye-hemostasis ye-tranexamic acid ifana ne-aminocaproic acid ne-aminomethylbenzoic acid, kodwa umphumela unamandla. Amandla izikhathi ezingu-7 kuya kwezingu-10 ze-aminocaproic acid, izikhathi ezingu-2 ze-aminomethylbenzoic acid, kodwa ubuthi buyafana.
Isakhiwo samakhemikhali se-tranexamic acid sifana ne-lysine, ukuvinjelwa kokuncintisana kwe-plasmin yasekuqaleni ku-adsorption ye-fibrin, ukuvimbela ukusebenza kwabo, ukuvikela amaprotheni e-fiber ukuthi angawohloki nge-plasmin futhi ahlakaze, ekugcineni afinyelele i-hemostasis. Isebenza ekwelapheni i-acute noma engapheli, yendawo noma ye-systemic primary fibrinolytic hyperthyroidism ebangelwa ukopha, njengokuphuma kwe-obstetric, ukopha kwe-renal, ukopha kwe-hypertrophy ye-prostate, i-hemophilia, i-pulmonary tuberculosis hemoptysis, ukopha kwesisu, ngemuva kokuhlinzwa kwesibindi, amaphaphu. , ubende nokunye ukopha kwe-viscera; futhi ingasetshenziswa ekuhlinzeni lapho ukopha okungavamile njll.
I-Clinical tranexamic acid inomphumela ophawulekayo ezifweni zokulunywa yizinambuzane, i-dermatitis kanye ne-eczema, i-purpura elula, i-urticaria engapheli, i-artificial sex urticaria, ukuqhuma okunobuthi nokuqhuma. Futhi inomphumela othile ku-erythroderma, scleroderma, systemic lupus erythematosus (SLE), Erythema multiforme, shingles kanye ne-alopecia areata. Ukwelashwa komphumela we-angioedema wefa nakho kuhle. Ekwelapheni i-Chloasma, umuthi ojwayelekile usebenza cishe amasonto ama-3, usebenza ngokuphawulekayo amaviki ama-5, inkambo yezinsuku ezingama-60. Inikezwa ngomlomo ngemithamo ye-0.25 ~ 0.5 g, ngosuku izikhathi ezi-3 ~ 4. Iziguli ezimbalwa zingaba nesicanucanu, ukukhathala, pruritus, ukungaphatheki kahle kwesisu, kanye nemiphumela engemihle yohudo ngemva kokunyamalala kwezimpawu zokuhoxa.
Izinkomba
Ukopha okuhlukahlukene okubangelwa i-hyperfibrinolysis eyinhloko noma engapheli, yendawo noma yesistimu; isimo sesibili se-hyperfibrinolytic esibangelwa ukuhlangana kwe-intravascular coagulation. Ngokuvamile ungasebenzisi lo mkhiqizo ngaphambi kwe-heparinization.
Ukuhlukumezeka noma ukopha ngokuhlinzwa ezicutshini nasezithweni ezinezivuseleli eziningi ze-plasminogen ezifana ne-prostate, urethra, amaphaphu, ubuchopho, isibeletho, izindlala ze-adrenal, kanye negilo.
Umphikisi we-tissue plasminogen activator (t-PA), i-streptokinase, ne-urokinase.
ukopha kwe-Fibrinolytic okubangelwa ukukhipha isisu okwenziwayo, ukuphuma kwe-placenta kwasekuqaleni, ukubeletha kanye ne-amniotic fluid embolism; kanye nokukhula kwe-menorrhagia okubangelwa yi-pathological intrauterine fibrinolysis.
I-Cerebral neuropathy ukopha okuncane, njengokuwopha kwe-subarachnoid kanye ne-intracranial aneurysm hemorrhage, umphumela we-Amstat kulesi simo ungcono kunowamanye ama-anti-fibrinolytic agents. Ukunakwa okukhethekile kufanele kukhokhwe engozini ye-cerebral edema noma i-cerebral infarction.Ezigulini ezinzima ezinezinkomba zokuhlinzwa, lo mkhiqizo ungasetshenziswa kuphela njengesidakamizwa se-adjuvant.
Ukwelashwa kwe-angioneurotic edema yofuzo, kunganciphisa inani nokuqina kweziqephu.
Isetshenziswa ezigulini ezine-hemophilia ukopha kwazo okusebenzayo kuhlanganiswe neminye imithi.
Iziguli ezine-hemophilia ezine-factor VIII noma ukushoda kwe-factor IX ekukhishweni kwazo kwamazinyo noma ezihlinzweni ngomlomo uma kwenzeka zopha.
