Incazelo emfushane:
Inombolo ye-CAS: 69004-03-1
Ifomula yemolekyuli:C18H14F3N3O4S
Isisindo se-molecule: 425.38
Isakhiwo samakhemikhali:
| Ulwazi Oluyisisekelo | |
| Igama lomkhiqizo | I-Toltrazuril |
| Inombolo ye-CAS. | 69004-03-1 |
| Umbala | Impushana emhlophe emhlophe noma ecishe ibe mhlophe |
| Ibanga | Okuphakelayo Ibanga |
| Isitoreji | Kuvalwe endaweni eyomile, Ngezinga lokushisa Legumbi |
| I-Shelf Life | iminyaka engu-2 |
| Sebenzisa | Izinkomo, Inkukhu, Inja, Inhlanzi, Ihhashi, Ingulube |
| Iphakheji | 25kg/isigubhu |
Incazelo
I-Toltrazuril (i-Baycox®,Procox®) iyisidakamizwa se-triazinon esithatha i-anticoccidial ebanzi kanye ne-antiprotozoalactivity. Ayitholakali kwezohwebo e-United States, kodwa iyatholakala kwamanye amazwe. Isebenza ngokumelene nezigaba zombili ze-asexual nezocansi ze-coccidia ngokuvimbela ukwehlukana kwenuzi kwama-schizonts nama-microga-monts kanye nemizimba eyakha udonga yama-macrogamonts. Kungase futhi kube usizo ekwelashweni kwe-neonatal porcinecoccidiosis, EPM, kanye ne-canine hepatozoonosis.
I-Toltrazuril kanye ne-metabolite yayo enkulu i-ponazuril (i-toltrazuril sulfone, i-Marquis) imithi ye-antiprotozoal esekelwe ku-triazine enomsebenzi othize ngokumelene nezifo ze-apicomplexan coccidial. I-Toltrazuril ayitholakali ngaphakathi kwe-United States.
Ukusetshenziswa komkhiqizo
Ingulube: I-Toltrazuril ikhonjiswe ukunciphisa izimpawu ze-coccidiosis ezingulubeni ezincelisayo ngokwemvelo lapho i-BWdose yomlomo eyodwa yomlomo engu-20–30 mg/kg inikezwa ezingulubeni ezi-3 kuya kweziyi-6 (Driesen et al., 1995). Izimpawu zomtholampilo zehliswa zisuka ku-71 zaya ku-22% wezingulube ezincelisayo, futhi isifo sohudo nokuphuma kwe-oocyst nakho kwehliswa ngokwelashwa komlomo okukodwa. Imikhiqizo egunyaziwe inesikhathi sokuhoxa sezinsuku ezingama-77 e-United Kingdom.
Amankonyane namawundlu: I-Toltrazuril isetshenziselwa ukuvimbela izimpawu zomtholampilo ze-coccidiosis kanye nokunciphisa ukuchithwa kwe-coccidia ematholeni nasemawundluni njengokwelashwa komthamo owodwa. Izikhathi zokuhoxa e-United Kingdom ziyizinsuku ezingama-63 nezingu-42 zamathole namawundlu, ngokulandelana.
Izinja: Nge-hepatozoonosis, i-toltrazuril enikezwa ngomlomo ku-5 mg/kg BW njalo emahoreni ayi-12 izinsuku ezingu-5 noma inikezwe ngomlomo ngo-10 mg/kg BW njalo emahoreni ayi-12 ngezinsuku eziyi-10 ibangele ukuxolelwa kwezimpawu zomtholampilo ezinjeni ezitheleleke ngokwemvelo ezinsukwini ezingu-2-3 ( UMacintire et al., 2001). Ngeshwa, izinja eziningi ezelashwayo zaphinde zafa futhi ekugcineni zabulawa yi-hepatozoonosis. Emidlwaneni ene-Isospora sp. ukutheleleka, ukwelashwa nge-emodepside engu-0.45 mg kuhlanganiswe no-9 mg/kg BW toltrazuril (Procox®, Bayer Animal Health) kunciphisa ukubalwa kwe-ocyst ye-fecal ngo-91.5–100%. Kwakungekho mehluko ngesikhathi sohudo lapho ukwelashwa kuqalwa ngemuva kokuqala kwezimpawu zomtholampilo ngesikhathi sokutheleleka kwelungelo lobunikazi (Altreuther et al., 2011).
Amakati: Emakatini ahlaselwe ukuhlolwa nge-Isospora spp., ukwelashwa ngethamo elilodwa lomlomo elingu-0.9 mg emodepside kuhlanganiswe no-18 mg/kg BW toltrazuril (Procox®, Bayer AnimalHealth) kunciphisa ukuchitheka kwe-oocyst ngo-96.7–100% uma kunikezwa ngesikhathi sokugunyazwa ngaphambi kwesikhathi. isikhathi (uPetry et al., 2011).
Amahhashi: I-Toltrazuril nayo isetshenziselwe ukwelashwa kwe-EPM. Lesi sidakamizwa siphephile, ngisho nangemithamo ephezulu. Imithi enconyiwe yamanje ingu-5–10 mg/kg ngomlomo izinsuku ezingama-28. Ngaphandle kokusebenza kahle kwe-toltrazuril, ukusetshenziswa kwayo kwehlile emahhashini ngenxa yokutholakala okungcono kweminye imithi esebenzayo.
