Incazelo emfushane:
Inombolo ye-CAS:51322-75-9
Ifomula ye-molecular:C9H8ClN5S
isisindo samangqamuzana:253.71
Isakhiwo samakhemikhali:
| Ulwazi Oluyisisekelo | |
| Igama lomkhiqizo | I-Tizanidine |
| Ibanga | Ibanga le-Pharma |
| Ukubukeka | Impushana Emhlophe |
| Isivivinyo | 99% |
| Impilo yeshelufu | iminyaka engu-2 |
| Ukupakisha | 25kg/isigubhu |
| Isimo | Gcina ku -20°C |
Uhlaka
I-Tizanidine iyi-imidazoline ephuma ku-nitrogen heterocyclic pentene. Isakhiwo sifana nese-clonidine. Ngo-1987, yafakwa okokuqala ohlwini eFinland njenge-adrenalin α2 receptor agonist emaphakathi. Njengamanje, isetshenziswa njenge-central muscle relaxant emtholampilo. Ingasetshenziselwa ukwelapha ubuhlungu bemisipha ebuhlungu, njenge-neck waist syndrome kanye ne-torticollis. Ingase futhi isetshenziselwe ukwelapha ubuhlungu be-postoperative, njenge-disc herniation kanye ne-hip arthritis. Ivela ku-ankylosis yokuphazamiseka kwezinzwa, njenge-multiple sclerosis, i-myelopathy engapheli, ingozi ye-cerebrovascular njll.
Umsebenzi
Isetshenziselwa ukunciphisa ukungezwani kwemisipha yamathambo, i-muscle spasm kanye ne-myotonia ebangelwa ukulimala kobuchopho nomgogodla, ukopha kobuchopho, i-encephalitis kanye ne-multiple sclerosis.
I-Pharmacology
Inciphisa ngokukhetha ukukhululwa kwama-amino acid ajabulisayo kusuka kuma-interneurons futhi ivimbela indlela ye-synaptic eminingi ehlobene nokucindezeleka kwemisipha. Lo mkhiqizo akuphazamisi ukudluliswa kwe-neuromuscular. Kubekezelelwa kahle. Isebenza ngempumelelo ezinhlungwini ezinzima zemisipha futhi i-ankylosis engapheli ivela kumgogodla kanye nobuchopho. Kunganciphisa ukumelana nokunyakaza kwe-passive, ukunciphisa i-spasticity kanye ne-clonus, futhi kwandise ukushuba kokunyakaza kokuzithandela.
Isebenzisa
Ilebulwe ngokuthi i-Tizanidine, ehloselwe ukusetshenziswa njengezinga langaphakathi lokulinganisa i-Tizanidine nge-GC- noma i-LC-mass spectrometry. I-Tizanidine ingaba nokusetshenziswa kokwelapha njenge-SARS-CoV-2 main protease inhibitor.
Ukusetshenziswa Kwezokwelapha
I-Tizanidine iyi-adrenergic α2 receptor agonist esebenza phakathi nendawo esetshenziselwa ukwelapha izimo ezingapheli zemisipha, njenge-multiple sclerosis.
Indlela yokwenza
I-Tizanidine iyi-analogue ye-clonidine ephumuza imisipha ephakathi nendawo egunyazwe ukusetshenziswa ekwehliseni i-spasticity ehambisana nokulimala kobuchopho noma komgogodla. Indlela yayo yokusebenza yokunciphisa i-spasticity iphakamisa ukuvinjelwa kwe-presynaptic yama-motor neurons ku-αIzingosi ze-2-adrenergic receptor, ukunciphisa ukukhululwa kwama-amino acids ajabulisayo futhi kuvimbele izindlela ezisizayo ze-ceruleospinal, ngaleyo ndlela kubangele ukuncipha kwe-spasticity. I-Tizanidine inengxenye encane kuphela yesenzo se-clonidine se-antihypertensive, mhlawumbe ngenxa yesenzo eqenjini elikhethiwe le-Clonidine.αI-2C-adrenoceptors, ebonakala inesibopho somsebenzi we-analgesic kanye ne-antispasmodic imidazolineα2-agonists(20).
