Incazelo emfushane:
Inombolo ye-CAS: 59-05-2
Ifomula yemolekyuli:C20H22N8O5
Isisindo se-molecule: 454.45
Isakhiwo samakhemikhali:
| Ulwazi Oluyisisekelo | |
| Igama lomkhiqizo | I-Methotrexate |
| Ibanga | Ibanga lezemithi |
| Ukubukeka | i-crystalline powder e-orange-yellow. |
| Isivivinyo | 99% |
| Impilo yeshelufu | iminyaka engu-2 |
| Ukupakisha | 25kg/ibhokisi |
| Isici | Izinzile, kodwa izwela ukukhanya futhi i-hygroscopic. Akuhambisani nama-acids aqinile, ama-oxidizing agents aqinile. |
| Isimo | Gcina endaweni emnyama, emkhathini ongangeni, Gcina efrijini, ngaphansi kuka -20°C |
Iyini i-Methotrexate?
I-Methotrexate izwela i-hydrolysis, i-oxidation nokukhanya. Ayincibiliki emanzini. I-Methotrexate ibola ezimweni ezine-asidi kakhulu noma ezine-alkali. I-Methotrexate ayihambisani nama-oxidizing agents aqinile nama-acids aqinile.
I-Methotrexate isidakamizwa esisetshenziselwa ukwelapha umdlavuza, owaziwa nangokuthi izidakamizwa ze-cytotoxic. Ukuze unciphise i-cytotoxicity, ingasetshenziswa kanye ne-calcium leucovorin. Ngokuyinhloko isetshenziselwa ukwelapha i-acute leukemia (i-acute lymphocytic leukemia), umdlavuza webele, imvukuzane eyingozi kanye ne-choriocarcinoma, umdlavuza wekhanda nentamo, umdlavuza wamathambo, i-leukemia, ukungena kwe-meningeal yomgogodla, umdlavuza wamaphaphu, umdlavuza wesistimu yokuzala, umdlavuza wesibindi, i-refractory. i-psoriasis vulgaris, i-dermatomyositis, i-myositis yomzimba, ukuvuvukala kwe-spondylitis ankylosing, isifo sika-Crohn, i-psoriasis nesifo samathambo e-psoriatic, isifo sikaBehcet kanye nesifo sokuzivikela komzimba. I-Methotrexate iyi-immuno suppressant futhi ingasetshenziselwa ukunciphisa inqubo ye-rheumatism ngempumelelo enhle kakhulu ekwelapheni ukuvuvukala kwe-synovial kwe-rheumatoid arthritis futhi iyimithi esetshenziswa kakhulu ukwelapha izifo ze-rheumatoid.
Isicelo somtholampilo
Isebenza ngempumelelo ekwelapheni i-acute leukemia ngokusebenza kangcono ezigulini zezingane. Isebenza kahle ekwelapheni i-choriocarcinoma kanye nemvukuzane eyingozi. Ukuphathwa komthamo omkhulu kusebenza ngempumelelo ekwelapheni i-osteosarcoma, i-sarcoma yezicubu ezithambile, umdlavuza wamaphaphu, umdlavuza wamasende, umdlavuza webele, nomdlavuza wesibeletho. Iyasebenza futhi ekwelapheni umdlavuza wekhanda nentamo, umdlavuza wesibindi kanye nomdlavuza wamathumbu. I-Arterial infusion yalo mkhiqizo inamandla e-goo ekwelapheni umdlavuza wekhanda nentamo kanye nomdlavuza wesibindi. Kodwa-ke, akuvamile ukusetshenziselwa ukwelapha i-psoriasis ne-psoriasis.
