Incazelo emfushane:
Inombolo ye-CAS: 15687-27-1
Ifomula yemolekyuli: C13H18O2
Isisindo se-molecule: 206.28
Isakhiwo samakhemikhali:
| Ulwazi Oluyisisekelo | |
| Igama lomkhiqizo | Ibuprofen |
| Inombolo ye-CAS. | 15687-27-1 |
| Umbala | Okumhlophe kuya kokumhlophe |
| Ifomu | I-Crystalline Powder |
| Ukuncibilika | Ayincibiliki emanzini, incibilika ngokukhululeka ku-acetone, ku-methanol naku-methylene chloride. Incibilika ezixazululweni ezixubile zama-alkali hydroxides nama-carbonates. |
| Ukuncibilika kwamanzi | engancibiliki |
| Ukuzinza | Izinzile. Okuvuthayo. Akuhambisani nama-oxidizing agents aqinile |
| I-Shelf Life | 2 Yizindlebe |
| Iphakheji | 25kg/Isigubhu |
Incazelo
II-buprofen ingeye-non-steroidal anti-inflammatory analgesic. Inomphumela omuhle kakhulu wokulwa nokuvuvukala, i-analgesic kanye ne-antipyretic enokusabela okuncane okubi. Isetshenziswe kakhulu emhlabeni, njengemithi edayiswa kakhulu emhlabeni wonke enganikezwanga. Yona, kanye ne-aspirin ne-paracetamol ibalwe njengemikhiqizo emithathu ebalulekile ye-antipyretic analgesics. Ezweni lakithi, isetshenziswa ikakhulukazi ekudambiseni izinhlungu kanye ne-anti-rheumatism, njll. Inezicelo ezincane kakhulu ekwelapheni amakhaza nomkhuhlane uma kuqhathaniswa ne-paracetamol ne-aspirin. Kunenqwaba yezinkampani ezithaka imithi ezifanelekele ukukhiqizwa kwe-ibuprofen eChina. Kepha ingxenye enkulu yokuthengiswa kwemakethe yasekhaya kwe-ibuprofen ithathwe yi-Tianjin Sino-US Company.
I-Ibuprofen yatholwa ngokuhlanganyela nguDkt. Stewart Adams (kamuva waba uprofesa futhi wazuza iNdondo yoMbuso WaseBrithani) kanye nethimba lakhe elihlanganisa u-CoLinBurrows noDkt. John Nicholson. Inhloso yocwaningo lokuqala kwakuwukwenza "i-aspirin ephezulu" ukuze kutholwe enye indlela yokwelapha isifo samathambo esiqhathaniseka naleyo ye-aspirin kodwa enemiphumela engemihle kangako. Kwezinye izidakamizwa ezifana ne-phenylbutazone, inengozi enkulu yokubangela ukucindezelwa kwe-adrenal nezinye izenzakalo ezimbi ezifana nezilonda zesisu. U-Adams wanquma ukubheka umuthi onokumelana kahle ne-gastrointestinal, obaluleke kakhulu kuwo wonke ama-non-steroidal anti-inflammatory drugs.
Izidakamizwa ze-Phenyl acetate zivuse isithakazelo sabantu. Yize eminye yale mishanguzo kutholakale ukuthi isengcupheni yokudala izilonda ngenxa yokuhlolwa kwenja, u-Adams uyazi ukuthi kungenzeka ukuthi lesi sigameko sidalwa wukuphila isikhathi eside kwesigamu sempilo yokukhishwa kwezidakamizwa. Kuleli klasi lezidakamizwa kukhona i-compound - ibuprofen, enesigamu sempilo emfushane, egcina amahora angu-2 kuphela. Phakathi kweminye imithi ehloliwe, nakuba ingasebenzi kakhulu, iyona evikeleke kakhulu. Ngo-1964, ibuprofen isiphenduke enye indlela ethembisa kakhulu kune-aspirin.
Izinkomba
Umgomo ovamile ekuthuthukisweni kwemithi yobuhlungu nokuvuvukala kube ukwakhiwa kwezinhlanganisela ezinekhono lokwelapha ukuvuvukala, umkhuhlane, nobuhlungu ngaphandle kokuphazamisa eminye imisebenzi yomzimba. Izidakamizwa ezijwayelekile zokunciphisa ubuhlungu, njenge-aspirin ne-ibuprofen, zivimbela kokubili i-COX-1 ne-COX-2. Ukucaciswa komuthi ku-COX-1 uma kuqhathaniswa ne-COX-2 kunquma amathuba okuba nemiphumela emibi emibi. Imithi enemininingwane ethe xaxa ku-COX-1 izoba namandla amakhulu okukhiqiza imiphumela emibi emibi. Ngokuvala i-COX-1, izidambisi zinhlungu ezingakhethiwe zandisa ithuba lemiphumela emibi engathandeki, ikakhulukazi izinkinga zokugaya ukudla ezifana nezilonda zesisu kanye nokopha kwesisu. I-COX-2 inhibitors, njenge-Vioxx ne-Celebrex, ivala ngokukhetha i-COX-2 futhi ayithinti i-COX-1 kumithamo enqunyiwe. I-COX-2 inhibitors inqunyelwe kabanzi ekwelapheni isifo sokuqaqamba kwamalunga nokukhululeka kobuhlungu. Ngo-2004, i-Food and Drug Administration (FDA) yamemezela ukuthi ingozi eyengeziwe yokuhlaselwa yinhliziyo nesifo sohlangothi yayihlotshaniswa nama-COX-2 inhibitors athile. Lokhu kuholele ekukhipheni amalebula ezixwayiso kanye nokukhishwa ngokuzithandela kwemikhiqizo emakethe ngabakhiqizi bezidakamizwa; isibonelo, i-Merck yakhipha i-Vioxx emakethe ngo-2004. Nakuba i-ibuprofen ivimbela kokubili i-COX-1 ne-COX-2, inezikhathi ezimbalwa zokucaciswa kwe-COX-2 uma kuqhathaniswa ne-aspirin, ikhiqiza imiphumela emibi embalwa yesisu..
