Ukuhlinzeka ngekhwalithi enhle 99%Impushana ye-Albendazole ehlanzekile, Impahla Eluhlaza Yezilwane

Sincike emandleni obuchwepheshe aqinile futhi siqhubeka sakha ubuchwepheshe obuyindida ukuze sanelise isidingo Sokuhlinzeka Ngekhwalithi Enhle 99%Impushana Ehlanzekile Ye-Albendazole, Impahla Engavuthiwe Yezilwane, Sihlale sibheke ngabomvu ukwakha ubudlelwano bebhizinisi obuphumelelayo nabathengi abasha emhlabeni wonke.
Sincike emandleni obuchwepheshe aqinile futhi sihlala sidala ubuchwepheshe obuyindida ukuze sanelise isidingoI-China Albendazole kanye ne-Pharmaceutical Chemical, Inkampani yethu ihlanganisa indawo 20, 000 square metres. Sinezisebenzi ezingaphezu kuka-200, ithimba lezobuchwepheshe elichwepheshile, isipiliyoni seminyaka engu-15, ubuciko obuhle kakhulu, izinga elizinzile nelithembekile, intengo yokuncintisana namandla okukhiqiza anele, le yindlela esenza ngayo amakhasimende ethu aqine. Uma unombuzo, khumbula ukuthi ungangabazi ukusithinta.

Incazelo

I-Albendazole (ALBENZA) iyi-anthelmintic elawulwa ngomlomo ebanzi. Ithebhulethi ehlafunwayo ye-Albendazole ifakwe ohlwini lweNhlangano Yezempilo Yomhlaba (i-WHO) yemithi ebalulekile njengomuthi we-anthelminthic wamathumbu kanye ne-antifilarial. Ithebhulethi ye-Albendazole yasungulwa ngabakwaSmithKline Animal Health Laboratories futhi yavunyelwa yi-US Food and Drug Administration (FDA) ngo-1996.
I-Albendazole inamandla okubulala ngokuphelele amaqanda ewhipworm kanye nezikelemu kanye nokubulala kancane amaqanda e-Ascaris; ingaphinde isuse izinhlobo ezahlukene zama-nematodes angena emizimbeni yezilwane, futhi ibe nomthelela ekususeni noma ekubulaleni ngokuqondile izikelemu zetapeworm kanye ne-cysticercci. Ngakho-ke iwusizo ekwelapheni i-hydatid kanye nesistimu yezinzwa (cysticercosis) ebangelwa ukutheleleka kwengulube yengulube, futhi nasekwelapheni i-hookworm, i-roundworm, i-pinworm, i-nematode trichinella, i-tapeworm, i-whipworm ne-stercoralis nematode.

I-Pharmacodynamics

I-Albendazole iwuhlobo lokuphuma kwe-benzimidazole. Igaywa ngokushesha ku-vivo ibe yi-sulfoksidi, i-sulfone kanye ne-2-polyamine sulfone alcohol. Ingacindezela ngokukhethayo nangokungaguquki ukumuncwa kwe-glucose ye-nematode yamathumbu, ngaleyo ndlela kuphumele ekuncipheni kwe-glycogen engapheli yesibungu; ngesikhathi esifanayo, iphinde ivimbele umsebenzi we-fumarate reductase, futhi ngaleyo ndlela ivimbele ukukhiqizwa kwe-adenosine triphosphate, ekugcineni ibangele ukufa kwama-parasites.
Ngokufanayo ne-mebendazole, ngokubangela ukuchithwa kwe-microtubules ye-cytoplasmic yama-parasites emathunjini kanye nokubopha ku-tubulin, kubangela ukuvinjelwa kokuthutha kwe-intracellular, okubangela ukuqoqwa kwezinhlayiya ze-Golgi endocrine; i-cytoplasm iyancibilika kancane kancane, okubangela ukufa kokugcina kwezimuncagazi.
Lo mkhiqizo ungabulala ngokuphelele amaqanda e-hookworm, amaqanda e-pinworm, amaqanda e-wool spin, amaqanda e-tapeworm kanye namaqanda e-cysticercosis ashaye futhi abulale amaqanda e-Ascaris kancane.

Ukusetshenziswa Okuvamile

I-Albendazole isidakamizwa esisetshenziselwa ukwelapha izifo ezibangelwa ama-parasites. Inganikezwa ukwelapha isifo sobuchopho esingavamile (i-neurocysticercosis) noma inganikezwa ukwelapha isifo esibangelwa isifo sohudo esibalulekile (microsporidiosis).

Ukusetshenziswa Kwezokwelapha

I-Albendazole inomkhakha obanzi wokusebenza ngokumelene ne-nematodes yamathumbu kanye ne-cestodes, kanye nama-flukes esibindi i-Opisthorchis sinensis, i-Opisthorchis viverrini, ne-Clonorchis sinensis. Iphinde isetshenziswe ngempumelelo ngokumelene ne-Giardia lamblia. Isetshenziswa kabanzi emhlabeni wonke ekwelapheni ukutheleleka kwe-intestinalnematode. Isebenza ngempumelelo njengokwelashwa ngomthamo owodwa we-ascariasis, izifo ze-hookworm ze-New and Old World, kanye ne-trichuriasis. Ukwelashwa kwemithamo eminingi nge-albendazole caneradicate pinworm, threadworm, capillariasis, clonorchiasis, nesifo se-hydatid. Ukusebenza kahle kwe-albendazole ngokumelene nezikelemu zetape (cestodes) ngokuvamile kuyaguquguquka futhi akukhangisi kangako. Isebenza ngempumelelo futhi ekwelapheni i-neurocysticercosis yobuchopho nomgogodla, ikakhulukazi uma inikezwa nge-dexamethasone.I-Albendazole iyanconywa ekwelapheni i-gnathostomiasis.

Sincike emandleni obuchwepheshe aqinile futhi siqhubeka sakha ubuchwepheshe obuyindida ukuze sanelise isidingo Sokuhlinzeka Ngekhwalithi Enhle 99%Impushana Ehlanzekile Ye-Albendazole, Impahla Engavuthiwe Yezilwane, Sihlale sibheke ngabomvu ukwakha ubudlelwano bebhizinisi obuphumelelayo nabathengi abasha emhlabeni wonke.
Ikhwalithi enhleI-China Albendazole kanye ne-Pharmaceutical Chemical, Inkampani yethu ihlanganisa indawo 20, 000 square metres. Sinezisebenzi ezingaphezu kuka-200, ithimba lezobuchwepheshe elichwepheshile, isipiliyoni seminyaka engu-15, ubuciko obuhle kakhulu, izinga elizinzile nelithembekile, intengo yokuncintisana namandla okukhiqiza anele, le yindlela esenza ngayo amakhasimende ethu aqine. Uma unombuzo, khumbula ukuthi ungangabazi ukusithinta.