Incazelo emfushane:
Inombolo ye-CAS: 1264-72-8
Ifomula yemolekyuli:2(C52H98N16O13).5(H2SO4)
Isisindo se-molecule: 2801.27
Isakhiwo samakhemikhali:
| Ulwazi Oluyisisekelo | |
| Igama lomkhiqizo | I-Colistin sulfate |
| Ibanga | Okuphakelayo Ibanga |
| Ukubukeka | Impushana emhlophe noma ecishe ibe mhlophe, eyi-hygroscopic |
| Isivivinyo | 99% |
| Impilo yeshelufu | iminyaka engu-2 |
| Ukupakisha | 20kg/ibhokisi 20kg/isigubhu |
| Isimo | Gcina ku -20 ℃ unyaka owodwa(Impushana） |
Incazelo yomkhiqizo
I-Colistin iyi-cyclic cationic decapeptide exhunywe ku-fatty acid side chain, iyingxenye yeqembu lama-peptide e-antimicrobial akhiwe ngendlela efanayo. I-Colistin sulfate iyimithi elwa namagciwane ye-polypeptide evimbela amagciwane ane-gram-negative ngokubopha kuma-lipopolysaccharides nama-phospholipids kulwelwesi lwamaseli olungaphandle lwebhaktheriya e-gram-negative.
I-Colistin sulfate, eyaziwa nangokuthi i-colistin sulfate, i-Christian (Colistin), i-Polymyxin E(i-Polymyxin E), i-antiphytin, impushana emhlophe noma ecishe ibe mhlophe, engenaphunga, umswakama obabayo, uncibilika kalula emanzini, inyibilika kancane ku-methanol, i-ethanol, cishe ayincibiliki i-acetone, i-ether, i-alkali yamahhala incibilika kancane emanzini. Izinzile kububanzi be-PH3-7.5. I-Mycolistin sulfate ikhiqizwa yi-Bacillus polymyxoides, enomphumela oqinile we-antibacterial kubhaktheriya e-gram-negative. Isetshenziselwa ukwelapha izifo zamathumbu ezibangelwa amagciwane e-gram-negative, futhi isetshenziswa njengesengezo sokuphakelayo esinomphumela obonakalayo okhuthaza ukukhula. Inhlanganisela yomphumela we-sulfadiazine ingcono.
Umsebenzi womkhiqizo
Ama-colistin sulfate granules athuthukile ekuzinzeni kwamandla ekuphakeleni nasekuboniseni ukuncibilika okuphezulu naphezu kokukhiqizwa kwawo ngaphandle kokusebenzisa noma iyiphi inkampani yenethiwekhi ebizayo noma imishini ekhethekile. Ikakhulukazi, ama-colistin sulfate granules ahlanganisa i-colistin sulfate futhi anezinhlayiyana ezinobubanzi obuyi-150 kuya ku-1500m, indawo ethize engu-40 kuya ku-500 cm2/g, isikhathi sokumanzisa esiyimizuzu emi-5 noma ngaphansi kanye nomswakama ongu-10 % noma ngaphansi.
I-Pharmacodynamics
I-Colistin iyi-ejenti ye-polymyxin ye-antibiotic. Ama-polymyxins ama-polypeptides e-cationic aphazamisa ulwelwesi lweseli yebhaktheriya ngomshini onjenge-detergent. Ngokuthuthukiswa kwama-ejenti anobuthi obuncane, njengama-penicillin ane-spectrum enwetshiwe kanye ne-cephalosporins, ukusetshenziswa kwe-polymyxin ye-parenteral kuyekwa kakhulu, ngaphandle kokwelashwa kwezifo zamaphaphu ezingazweli ezigulini ezine-cystic fibrosis.
