Incazelo emfushane:
Inombolo ye-CAS:24729-96-2
Ifomula yemolekyuli:C18H34ClN2O8PS
isisindo samangqamuzana:504.96
Isakhiwo samakhemikhali:
| Ulwazi Oluyisisekelo | |
| Igama lomkhiqizo | I-Clindamycin Phosphate |
| Ibanga | Ibanga le-Pharma |
| Ukubukeka | impushana emhlophe |
| Isivivinyo | 95% |
| Impilo yeshelufu | iminyaka engu-2 |
| Ukupakisha | 25kg/isigubhu |
| Isimo | Izinzile, kodwa igcina ipholile. Akuhambisani nama-oxidizing agents aqinile, i-calcium gluconate, i-barbiturates, i-magnesium sulfate, i-phenytoin, amavithamini e-sodium eqembu B. |
Incazelo
I-Clindamycin phosphate i-ester encibilika emanzini ye-semisynthetic antibiotic ekhiqizwa i-7 (S)-chloro-substitution yeqembu le-7 (R)-hydroxyl le-antibiotic engumzali, i-lincomycin. Iphuma ku-lincomycin (i-lincosamide). Inesenzo se-bacteriostatic ngokuyinhloko ngokumelene ne-Gram-positive aerobes kanye nohlu olubanzi lwe-anaerobicbacteria. Kuyi-antibiotic ye-topical esetshenziswa ekwelapheni izifo. Lokhu kungabandakanya izifo zepheshana lokuphefumula, i-septicaemia, i-peritonitis kanye nezifo zamathambo. Ibuye isetshenziselwe ukwelapha izinduna ezimaphakathi kuya kwezinzima.
Sebenzisa
I-Clindamycin phosphate isetshenziswa ngokwezihloko iyodwa noma ngokuhambisana ne-benzoyl peroxide ekwelapheni i-acne vulgaris evuthayo. Lapho kukalwa izinzuzo ezingaba khona zokwelashwa kwe-clindamycin ye-topical, kufanele kubhekwe ukuthi kungenzeka kube nemiphumela emibi kakhulu ye-GI ehambisana nomuthi. Ukwelashwa kwe-acne vulgaris kufanele kube ngabanye futhi kushintshwe njalo kuye ngezinhlobo zezilonda ezivame kakhulu kanye nokusabela ekwelashweni. Ama-anti-infective ama-topical, okuhlanganisa i-clindamycin, ngokuvamile ayasebenza ekwelapheni izinduna ezivuvukalayo ezithambile kuya kwezimaphakathi. Kodwa-ke, ukusetshenziswa kwezidakamizwa ezilwa namagciwane njenge-monotherapy kungase kuholele ekuphikisweni kwamagciwane; lokhu kumelana kuhlotshaniswa nokuncipha kokuphumelela emtholampilo.I-clindamycin yesihloko iwusizo ikakhulukazi uma isetshenziswa ne-benzoyl peroxide noma i-topical retinoids. Imiphumela yezifundo zomtholampilo ikhombisa ukuthi ukwelashwa okuhlangene kuholela ekwehleni kwenani eliphelele lezilonda ngama-50-70%.
I-Clindamycin 2-phosphate iwusawoti we-clincamycin, i-semi-synthetic lincosamide. Usawoti ulungiswa nge-phosphorylation ekhethiwe ye-2-hydroxy moiety kashukela we-clindamycin. Ukwethulwa kwe-phosphate kunikeza ukuncibilika okuthuthukisiwe kokwenziwa komjovo. Njengamanye amalungu omndeni we-lincosamide, i-clindamycin 2-phosphate iyimithi elwa namagciwane ene-spectrum ebanzi enomsebenzi omelene namagciwane anaerobic nama-protozoans. I-Clindamycin isebenza ngokubophezela ku-23S ribosomal subunit, ivimbele ukuhlanganiswa kwamaprotheni.
