Incazelo emfushane:
Inombolo ye-CAS: 27164-46-1
Ifomula yemolekyuli: C14H15N8NaO4S3
isisindo se-molecule: 478.5
Isakhiwo samakhemikhali:
| Ulwazi Oluyisisekelo | |
| Igama lomkhiqizo | Cefazolin sodium usawoti |
| Inombolo ye-CAS. | 27164-46-1 |
| Ukubukeka | Impushana yekristalu emhlophe ukuya kokumhlophe |
| Ibanga | I-Pharma Grade |
| Isitoreji | Gcina endaweni emnyama, emkhathini ongenayo, 2-8°C |
| I-Shelf Life | iminyaka engu-2 |
| Ukuzinza | Izinzile, kodwa ingase izwele ukushisa - gcina ezimeni ezipholile. Ingashintsha umbala lapho uchayeka ekukhanyeni - gcina ebumnyameni. Akuhambisani nama-oxidizing agents aqinile. |
| Iphakheji | 25kg/Isigubhu |
Incazelo Yomkhiqizo
Imithi elwa namagciwane eyi-semisynthetic equkethe i-cephalosporins ku-molecule ye-cephalosporins. Kuhunyushwe njenge-Xianfeng mycin. okuka-β-Ama-antibiotic e-Lactam, yebo β- Okuphuma ku-7-aminocephalosporanic acid (7-ACA) kuma-antibiotic e-lactam kunezindlela ezifanayo zokubulala amagciwane. Lolu hlobo lomuthi lungabhidliza udonga lwamaseli amagciwane futhi luwabulale ngesikhathi sokuzala. Inomphumela oqinile wokukhetha kuma-bacterium futhi cishe ayinabo ubuthi kubantu, ngezinzuzo ezinjenge-spectrum ebanzi ye-antibacterial, umphumela oqinile we-antibacterial, ukumelana nama-enzyme e-penicillin, kanye nokungezwani okuncane uma kuqhathaniswa ne-penicillin. Ngakho-ke iyi-antibiotic ebalulekile esebenza kahle kakhulu, ubuthi obuphansi, kanye nokusetshenziswa komtholampilo okubanzi. Isizukulwane sokuqala i-cephalosporins yathuthukiswa ngaphambili, inomsebenzi onamandla wokulwa namagciwane uma iqhathaniswa ne-Chemicalbook, i-spectrum ye-antibacterial emincane, kanye nemiphumela engcono yamagciwane e-anti Gram positive kune-Gram negative bacteria. Ikhiqizwe yi-Staphylococcus aureus β- I-Lactamase izinzile futhi ingavimbela ukukhiqizwa kwamagciwane angenayo i-β- Lactamases ayizinzile futhi isengakhiqizwa amagciwane amaningi e-Gram negative β- Alinyazwe ama-lactamase. I-Cefazolin sodium iyi-semisynthetic yesizukulwane sokuqala se-cephalosporin enemiphumela yokulwa namagciwane kuwo womabili amagciwane egram-positive kanye negram-negative. Ivame ukusetshenziswa ezifweni zesistimu yokuphefumula, uhlelo lwe-urogenital, izicubu ezithambile zesikhumba, ithambo kanye ne-joint, kanye ne-biliary tract ebangelwa amagciwane azwelayo, kanye ne-endocarditis, i-sepsis, i-pharyngeal kanye nezifo zendlebe. Inomsebenzi onamandla wokulwa namagciwane anegram-positive afana ne-Staphylococcus aureus ne-Streptococcus (ngaphandle kwe-Enterococcus), futhi iphakeme kune-cephalosporins yesibili yesizukulwane Sesithathu.
Ukusetshenziswa Kwekhemikhali
I-Cefazolin (i-Ancef, i-Kefzol) ingenye yochungechunge lwe-semisyntheticcephalosporins lapho umsebenzi we-C-3 acetoxy usuthathelwe indawo yi-heterocycle ene-thiol-lapha, i-5-methyl-2-thio-1,3,4-thiadiazole. Futhi iqukethe iqembu elingajwayelekile le-tetrazolylacetyl acylating. I-Cefazolin yakhululwa ngo-1973 njengosawoti we-sodium oncibilikayo emanzini. Isebenza kuphela ngokuphathwa kwe-parenteral.
I-Cefazolin inikeza amazinga aphezulu e-serum, ukukhululeka kancane kokuphindisela, kanye nesigamu sempilo ende kunamanye ama-cephalosporin esizukulwane sokuqala. Cishe i-75% ye-inplasma eboshelwe amaprotheni, inani eliphakeme kunamanye ama-cephalosporin amaningi. Ucwaningo lwakuqala lwe-in vitro nolwemitholampilo luphakamisa ukuthi i-cefazolin isebenza kakhulu ngokumelene ne-Gram-negative bacilli kodwa ingasebenzi kakhulu uma iqhathaniswa ne-Gram-positive cocci kune-cephalothin orcephaloridine. Amazinga okwenzeka kwe-thrombophlebitis elandela umjovo ophuma emthanjeni kanye nobuhlungu endaweni yomjovo we-intramuscular abonakala ephansi kakhulu kuma-parenteralcephalosporins.
