Incazelo emfushane:
Inombolo ye-CAS:590-63-6
Ifomula ye-molecular:C7H17ClN2O2
isisindo samangqamuzana:196.68
Isakhiwo samakhemikhali:
| Ulwazi Oluyisisekelo | |
| Igama lomkhiqizo | Bethanechol |
| Ibanga | Ibanga le-Pharma |
| Ukubukeka | impushana emhlophe |
| Isivivinyo | 95% |
| Impilo yeshelufu | iminyaka engu-2 |
| Ukupakisha | 25kg/isigubhu |
| Isimo | Indawo Epholile Neyomile |
Incazelo
I-Bethanechol iyi-ester yokwenziwa ngokwesakhiwo kanye ne-pharmacologically ehlobene ne-acetylcholine. I-agonist ye-muscarinic ene-hydrolyzed kancane engenamiphumela ye-nicotinic, i-bethanechol ngokuvamile isetshenziselwa ukukhulisa ithoni yemisipha ebushelelezi, njengasepheshaneni le-GI ngemva kokuhlinzwa kwesisu noma ekugcinweni komchamo ngaphandle kokuvinjelwa. Kungase kubangele i-hypotension, ukushintsha kwezinga lenhliziyo, kanye ne-bronchial spasms.
I-Bethanechol i-agonist ye-muscarinic acetylcholine receptors enamanani e-IC50 we-1,837, 25, 631, 317, kanye ne-393 μM ye-M1-5, ngokulandelana, ekuhlolweni kokubopha kwe-radioligand kusetshenziswa amaseli e-CHO aveza ama-receptors abantu. Ivimbela ukwanda kwe-M2-mediated ku-AMP ye-cyclic eyenziwa yi-isoproterenol ku-guinea pig eyedwa emathunjini amancane (IC50 = 127 μM). I-Bethanechol inyusa ithoni ye-basal ye-porcine ehlukile ye-intravesical ureter (EC50 = 4.27 μM). Iphinde ibangele uketshezi lwamanzi ku-ileum, duodenum, kanye ne-jejunum yamagundane ane-anesthetized lapho ilawulwa ngesilinganiso se-60 μg / kg. Amafomula aqukethe i-bethanechol asetshenziselwe ukukhulisa ukuchama nokuthuthukisa ithoni yemisipha ebushelelezi epheshaneni lamathumbu.
Ukusetshenziswa Kwezokwelapha
Ukusetshenziswa okuyinhloko kwe-bethanechol chloride kukhulula ukugcinwa komchamo kanye nokuvuleka kwesisu ngemva kokuhlinzwa.Umuthi usetshenziswa ngomlomo nangomjovo ongaphansi kwesikhumba. Akufanele neze iphathwe ngomjovo we-intramuscular noma nge-intravenous ngenxa yengozi evela ku-cholinergic overstimulation kanye nokulahlekelwa isenzo esikhethiwe. Ukuphathwa ngendlela efanele komuthi kuhlotshaniswa nobuthi obuphansi futhi akukho miphumela emibi kakhulu. I-Bethanechol chloride kufanele isetshenziswe ngokuqapha iziguli ezine-asthmatic; uma isetshenziselwa i-glaucoma, ikhiqiza ubuhlungu bekhanda obungaphambili kusukela ekuvinjweni kwe-sphinctermuscle esweni kanye nokuxhunyaniswa kwemisipha ye-ciliary. Ubude bayo besenzo yihora elingu-1.
Izidakamizwa kanye Nokwelashwa Kwezilwane
Emithini yezilwane, i-bethanechol isetshenziswa ngokuyinhloko ukuvuselela ukufinyela kwesinye ezilwaneni ezincane. Ingasetshenziswa futhi njengesikhuthazi se-esophageal noma esijwayelekile se-GI, nakuba i-metoclopramide kanye/noma i-neostigmine iye yayithatha kakhulu esikhundleni salokhu kusetshenziswa.
