Incazelo emfushane:
Inombolo ye-CAS: 7177-48-2
Ifomula yemolekyuli:C16H25N3O7S
Isisindo se-molecule: 403.45
Isakhiwo samakhemikhali:
| Ulwazi Oluyisisekelo | |
| Igama lomkhiqizo | I-Ampicillin |
| Ibanga | IBanga Lezemithi |
| Ukubukeka | Impushana emhlophe noma ecishe ibe mhlophe |
| Isivivinyo | |
| Impilo yeshelufu | iminyaka engu-2 |
| Ukupakisha | 25kg/isigubhu |
| Isimo | agcinwe endaweni epholile neyomile |
Incazelo
Njengeqembu le-penicillin lama-beta-lactam antibiotics, i-Ampicillin iyi-penicillin yokuqala ebanzi, enomsebenzi we-in vitro ngokumelene ne-Gram-positive ne-Gram-negative aerobic kanye ne-anaerobic bacteria, evame ukusetshenziselwa ukuvimbela nokwelapha izifo ezibangelwa amagciwane emgudwini wokuphefumula, umchamo. ipheshana, indlebe ephakathi, ukona, isisu namathumbu, isinye, nezinso, njll. okubangelwa amagciwane angena kalula. Iphinde isetshenziselwe ukwelapha i-gonorrhea engaxakile, i-meningitis, i-endocarditis salmonellosis, nezinye izifo ezimbi kakhulu ngokulawulwa ngomlomo, umjovo we-intramuscular noma ngokujova ngomthambo. Njengawo wonke ama-antibiotic, ayisebenzi ekwelapheni izifo ezibangelwa amagciwane.
I-Ampicillin isebenza ngokubulala amagciwane noma ngokuvimbela ukukhula kwawo. Ngemva kokungena amagciwane e-Gram-positive kanye ne-Gram-negative, isebenza njenge-inhibitor engenakuhlehliswa ye-enzyme transpeptidase edingwa amagciwane ukuze enze udonga lwamaseli, okuholela ekuvinjweni kokwakhiwa kodonga lwamangqamuzana futhi ekugcineni kuholele ku-cell lysis.
Umsebenzi we-antimicrobial
I-Ampicillin ayisebenzi kancane kune-benzylpenicillin ngokumelene namagciwane amaningi e-Gram-positive kodwa isebenza kakhulu ngokumelene ne-E. faecalis. I-MRSA kanye nezinhlobo ze-Str. I-pneumoniae enokuncipha kokungenwa yi-benzylpenicillin awazweli. Iningi leqembu D streptococci, anaerobic Gram-positive cocci kanye bacilli, kuhlanganise L. monocytogenes, Actinomyces spp. kanye ne-Arachnia spp., ingathinteka. I-Mycobacteria ne-nocardia azikwazi ukumelana.
I-Ampicillin inomsebenzi ofanayo ne-benzylpenicillin ngokumelene ne-N. gonorrhoeae, N. meningitidis kanye ne-Mor. i-catarrhalis. Isebenza ngokuphindwe izikhathi ezingu-2-8 kune-benzylpenicillin ngokumelene ne-H. influenzae kanye ne-Enterobacteriaceae eminingi, kodwa izinhlobo ezikhiqiza i-β-lactamase zimelana. I-Pseudomonas spp. ziyamelana, kodwa iBordetella, Brucella, Legionella kanye neCampylobacter spp. zivame ukuba sengozini. Ama-anaerobes athile e-Gram-negative afana ne-Prevotella melaninogenica kanye ne-Fusobacterium spp. ziyathinteka, kodwa i-B. fragilis imelana, kanjalo ne-mycoplasmas ne-rickettsiae.
Umsebenzi omelene nezinhlobo ze-molecular class A β-lactamase-producing of staphylococci, gonococci, H. influenzae, Mor. i-catarrhalis, i-Enterobacteriaceae ethile kanye ne-B. fragilis ithuthukiswa ukuba khona kwe-β-lactamase inhibitors, ikakhulukazi i-clavulanic acid.
Umsebenzi wayo we-bactericidal ufana nowe-benzylpenicillin. Ukuhlangana kwe-bactericidal kwenzeka nama-aminoglycosides ngokumelene ne-E. faecalis nama-enterobacteria amaningi, kanye ne-mecillinam ngokumelene nenani le-enterobacteria elimelana ne-ampicillin.
